F.I.S.H. is a non-invasive procedure implemented to determine the presence of chromosomal aberration. Applied to urine specimens, it detects DNA alterations in bladder cells. A DNA probe labeled with a fluorescent marker generates an observable signal via microscopic analysis.
OUR F.I.S.H. is a molecular urine test that use DNA probes to identify chromosomal abnormalities with 96% specificity. Through the use of four color probes they detect and quantify chromosomes 3, 7, 9 and 17. Abnormal cells are identified through microscopic examination.
A positive F.I.S.H. test result signifies chromosome abnormalities of bladder cells were detected, indicating further cystoscopy and bladder biopsy may be needed.
Benefits include earlier cancer cell detection through urine cytology thus providing greater dependability. Cystoscopy examines only the abnormal appearance of bladder wall tissue and misidentifies 26% of cancer cases. However, the combination of Uro-FISH with Cystoscopy greatly imrpoves cancer identification with only a 3% error rate.
